Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

Celalettin Eroglu, Oguz Galip Yildiz, Recep Saraymen, Serdar Soyuer, Eser Kilic, Servet Ozcan

Abstract


Purpose: To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats.

Methods: To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing the rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and malondiadehyde (MDA), nitric oxide (NO) levels were evaluated in lung tissue.

Results: Administration of AG resulted in an increase in the activities of CAT, SOD and GSHPx in the lungs. All were reduced after radiatio. In addition, AG administration resulted in a decrease in both NO and MDA levels in lung compared with the irradiated group.

Conclusion: Amnoguanidine increased the endogenous antioxidant defence mechanism in rats and protected the animals from radiation-induced lung toxicity. Moreover, AG may protect against ionizing radiation-induced lung damage because of its antioxidant effect.

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DOI: http://dx.doi.org/10.25011/cim.v31i4.4778

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