CSCI Young Investigators Forum Abstracts

Abstract

ASSESSMENT OF PARALLEL SIGNALING PATHWAYS IN UTERINE MYOCYTES STIMULATED WITH VARIOUS SMOOTH MUSCLE AGONISTS
H.N. Aguilar, B.F. Mitchell 1

TRACTOGRAPHY: A NOVEL TECHNIQUE TO IMAGE FIBER TRACTS OF THE SPINAL CORD
Fahad Alkherayf, Eve Tsai, Arturo Cardenas-Blanco,
Alain Berthiaume, Brien Benoit, John Sinclair 1

MODULATION OF OSTEOCLASTOGENESIS IN INFLAMMATORY JOINT DISEASES
H. Allard-Chamard, M. Durant, A.J. de Brum-Fernandes, G. Boire, S.V. Komarova, S.J. Dixon, S.M. Sims, R. Harison,
M.F. Manolson 2

“THE RIGHT THING TO DO? A CRITICAL ANALYSIS OF PUBLIC HEALTH ETHICS, RIGHTS DISCOURSE, AND THE EXPANSION OF ANTIRETROVIRAL THERAPY (ART)”
Berkhout, SG, Anderson, S, Tyndall, MW 2

COST-EFFECTIVENESS OF IMMEDIATE BASELINE COMPUTED TOMOGRAPHY VS. MAGNETIC RESONANCE IMAGING OF ACUTE ISCHEMIC STROKE IN ONTARIO PATIENTS WHO PRESENT WITH SYMPTOMS SUGGESTIVE OF STROKE
KR Burton, G. Mery 3

CHITOSAN-MEDIATED FGF18 DELIVERY FOR ASSISTED BONE REPAIR
A. Carli, M. Lavertu, C. Gao, A. Merzouki, M.D. Buschmann,
J.E. Henderson, E.J.Harvey 3

ACTIVE PI3K-AKT SIGNALING PROMOTES THE METASTATIC POTENTIAL OF ASCITES-DERIVED EPITHELIAL OVARIAN CANCER CELLS
Correa RJM, Ramos-Valdes Y, Bertrand M, Lanvin D,
Préfontaine M, Sugimoto AK, Lewis JD, Shepherd TG,
DiMattia GE 4

MECHANISMS OF K65R, D67N, K103N, V106M AND M184V RESISTANCE DEVELOPMENT IN SUBTYPE-B AND C HIV-1
Dimitrios Coutsinos, Cedric F. Invernizzi, Daniela Moisi,
Maureen Oliveira, Hongtao Xu, Bluma G. Brenner,
Mark A. Wainberg 4

A MODEL TO DETERMINE FACTORS INVOLVED IN THE INDUCTION OF AN IN VIVO CTL RESPONSE
Dissanayake D, Ohashi PS 5

P63 ANTAGONIZES P53 TO PROMOTE THE SURVIVAL OF EMBRYONIC NEURAL PRECURSOR CELLS
Sagar B. Dugani, Annie Paquin, Masashi Fujitani,
David R. Kaplan, Freda D. Miller 5

SPINAL LOCOMOTOR NETWORK MODULATION BY ENDOGENOUS SEROTONIN IN THE ISOLATED NEONATAL MOUSE SPINAL CORD
Dunbar MJ, Whelan PJ 6

THE TUMOR PROMOTING AND REPRESSING EFFECTS OF INTEGRIN-LINKED KINASE ARE DIFFERENTIATED BY JNK1 IN HUMAN CANCER CELLS
Adam David Durbin, Gregory Edward Hannigan,
David Malkin 6

INCREASED EXCITATION IN MICE OVER-EXPRESSING NEUROLIGIN-1 IS ASSOCIATED WITH IMPAIRED LONG-TERM POTENTIATION AND LEARNING AND MEMORY
Brennan D Eadie, Timal Kannangara, Regina Dalhaus,
Rochelle M Hines, Yu-Tian Wang, Alaa El-Husseini,
Brian R Christie 7

A NOVEL ROLE FOR CDK5/P35 IN MEDULLOBLASTOMA FORMATION
Friesen AN, Shin J, Law V, Lee YS, Mckinnon P, Lee KY 7

ALTERED PSYCHOSOCIAL BEHAVIOUR AND STRESS RESPONSE FOLLOWING ‘MINOR’ STROKE IN THE RAT
Krista Hewlett, Meighan Kelly, Dale Corbett 8

TUMOUR PATHOLOGY PREDICTS MICROSATELLITE INSTABILITY IN COLORECTAL CANCER
AJ Hyde, D Fontaine, S Stuckless, RC Green, A Pollett,
M Simms, P Parfrey, HB Younghusband 8

PROTEINASE-ACTIVATED RECEPTOR-2 (PAR2) IS A POTENTIAL TARGET FOR THE ANTI-INFLAMMATORY EFFECTS OF INSULIN
Eric Hyun, Rithwick Ramachandran, Nicolas Cenac,
Steeve Houle, Amit Saxena, Roland S. Liblau, Morley Hollenberg,
Nathalie Vergnolle 9

CHEMOSENSITIVE PROPERTIES OF THE VENTRAL MEDULLA IN VITRO
Kalf Daniel J, Wilson Richard JA 9

NOVEL DOPAMINE RECEPTOR-N TYPE CALCIUM CHANNEL INTERACTIONS: POTENTIAL THERAPEUTIC TARGETS FOR DISORDERS ASSOCIATED WITH ABERRANT DOPAMINERGIC SIGNALLING
Alexandra E. Kisilevsky, Sean J. Mulligan,
Christophe Altier, Mircea C. Iftinca, Diego Varela, Chao Tai,
Lina Chen, Shahid Hameed, Jawed Hamid, Brian A. MacVicar,
Gerald W. Zamponi 10

TRUNCATION OF THE C-TERMINAL DOMAIN OF CONNEXIN43 INCREASES INFARCT VOLUME DURING STROKE
Kozoriz MG, Bechberger JF, Bechberger GR, Suen MWH,
Moreno AP, Maass K, Willecke K, Naus CC 10

EVALUATION OF THE DELIVERABILITY AND TOLERABILITY OF INTENSIVE WEEKLY DOUBLET ADJUVANT CHEMOTHERAPY IN NON SMALL CELL LUNG CANCER
M. Sara Kuruvilla, Lorraine Martelli-Reid, J. R. Goffin,
A. Arnold, Peter M. Ellis 11

A POLICY-ORIENTED SYSTEMATIC REVIEW OF THE SAFETY AND EFFICACY OF ENDOSCOPIC THERAPIES FOR THE TREATMENT OF BARRETT’S ESOPHAGUS
Lau D, Menon D, Stafinski T, Topfer LA, Walker J 11

THE SRC-LIKE ADAPTOR PROTEIN, SLAP, PLAYS A ROLE IN MONOCYTE-DERIVED DENDRITIC CELL MATURATION
Larissa Liontos, L Dragone, A Weiss, C J McGlade 12

SWEET PEE: A NEW MOUSE MODEL FOR GLOMERULOCYSTIC KIDNEY DISEASE AND GLUCOSURIA
J Ly, J Rossant, L Oxborne, C McKerlie, A Flenniken,
S Quaggin 12

CARDIOGENIC SHOCK IN ASPHYXIATED NEONATE PIGLETS: IS COMBINATION INOTROPE THERAPY BETTER THAN HIGH-DOSE DOPAMINE?
N. Manouchehri, P.-Y. Cheung, C. Joynt, T. Churchill,
D. Bigam 13

THE RELATIONSHIP BETWEEN FLOW-MEDIATED DILATION, HYPEREMIC SHEAR STRESS, AND VARIOUS ANTHROPOMETRIC INDICES OF OBESITY
Martin BJ, Title LM, Verma S, Charbonneau F, Buithieu J,
Lonn EM, Anderson TJ 13

RAPID LOCALIZATION OF NEUTROPHILS TO SITES OF CELL DEATH BY MAC1-DEPENDENT ADHESION AND INTRAVASCULAR CRAWLING
McDonald B, Menezes GB, Kubes P 14

THE ROLE OF SHIP-1 IN CEACAM1-MEDIATED HOST RESPONSES TO NEISSERIA GONORRHOEAE INFECTION
Gordon G McSheffrey, S D Gray-Owen 14

USING VOLTAGE-SENSITIVE DYES TO RECORD BRAIN ACTIVITY IN NATURALLY MOVING MICE
McVea DA, Mohajerani MH, Fingas M, Murphy TH 15

POTENTIAL MECHANICAL INFLUENCE IN MICROVASCULAR PATHOLOGY IN THE ACL DEFICIENT RABBIT KNEE
Daniel Miller 15

OSTEOBLAST MECHANOSENSITIVITY: THE ROLE OF HYDROSTATIC PRESSURE
Kenneth A. Myers, Timothy Douglas, Ricarda Hess,
Justin Parreno, Jerome B. Rattner, Dieter Scharnweber,
Nigel G. Shrive, David A. Hart 16

ENDOTHELIAL PROGENITOR CELLS FOR HEALING AND ANGIOGENESIS IN A SEGMENTAL BONE DEFECT MODEL: A COMPARISON WITH MESENCHYMAL STEM CELLS
Nauth A, Li R, Schemitsch EH 16

DELAY OF DNA METHYLATION IN PERINATAL MALE GERM CELLS IN THE ABSENCE OF DNMT3L RESULTING IN INFERTILITY
Kirsten Niles, Sophie La Salle, Christopher Oakes,
Jacquetta Trasler 17

INVESTIGATING CRMP4 FUNCTION IN CNS NERVE REGENERATION
S. Ong Tone, S. Kanagal, A. Wilson, Y.Z. Alabed, A. Di Polo,
A.E. Fournier 17

A NOVEL, DNA DAMAGE-DEPENDENT REGULATORY PATHWAY FOR AKT IN VIVO
Andrew J. Perrin, W. Brent Derry 18

CHOP AS A TARGET FOR PRESERVATION OF TRANSPLANTED ISLET GRAFT MASS
Potter K, Dai L, Verchere CB 18

TREATMENT OF ACHILLES TENDINOPATHY
R Ram, C Patel, D Wiseman, W Meeuwisse, JP Wiley 19

PLACENTAL LACTOGEN FUNCTION IN POST-IMPLANTATION MURINE PREGNANCY
Saara M. Rawn, James C. Cross 19

DECODING NEURAL SIGNALS FROM MULTIELECTRODE ARRAYS IN THE PRIMATE DORSOLATERAL PREFRONTAL CORTEX
Sachs A.J, Pieper F, Martinez-Trujillo J.C. 20

THE ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN A MOUSE MODEL OF OSTEOARTHRITIS
Usmani S.E, Appleton C.T.G., Welch I.D, Beier F. 20

SKIN-DERIVED STEM CELLS ACT AS FUNCTIONAL SCHWANN CELLS WHEN TRANSPLANTED INTO LESIONED PERIPHERAL NERVE
Sarah K. Walsh, Rajiv Midha 21

TLR4 MEDIATES SUSCEPTIBILITY TO STREPTOZOTOCIN-INDUCED DIABETES
C Westwell-Roper, G Soukhatcheva, MJH Hutton, JP Dutz,
CB Verchere 21

A FUSION OF GMCSF AND IL-21 (GIFT-21) POTENTLY INDUCES INFLAMMATION AND APOPTOSIS THROUGH SIGNALS DOWNSTREAM OF THE IL-21R ALPHA CHAIN
Patrick Williams, Shala Yuan, Jessica Cuerquis,
Elena Birman, Kathy Ann Forner, Jacques Galipeau 22